Dysfunctional uterine bleeding in perimenopausal period

Dysfunctional uterine bleeding in perimenopausal period

Dr. Davari

Associate professor of TUMS

Reproductive endocrinologist

•  Chronic heavy or prolonged uterine bleeding is a common gynecologic problem.
• ovulatory or anovulatory.
•  Chronic heavy or prolonged uterine bleeding can result in anemia, interfere with daily activities, and raise concerns about uterine cancer.

TERMINOLOGY

•  The average menstrual cycle  seven days, the amount of menstrual blood loss is 35 to 40 mL per cycle.
• Menorrhagia is defined > 80 mL.
• Ovulatory or anovulatory

PREVALENCE AND IMPACT 

• Approximately 10 to 35 percent of women report having menorrhagia .
• Iron deficiency anemia develops in 21 to 67 percent of cases [2,10].
•  Excessive and irregular bleeding can detract from quality of life.
• Absenteeism from work or school is bothersome to many women and bleeding may also interfere with sexual activity.

Menopausal transition

•  During the menopausal transition, women can also have heavy or prolonged bleeding due to uterine structural abnormalities.
•  In addition, endocrine abnormalities commonly contribute to abnormal bleeding .
• In this group, intermittent anovulation often occurs and results in extended periods of estrogen production unopposed by progesterone, resulting in continued proliferation of the endometrium.